Over the last two decades, the use of serious games in several fields like learning, simulation, training, health, well-being, management, assessment or marketing exploded. We gained a deeper knowledge on their efficiency and effectiveness, in particular taking into consideration the needs of the digital natives’ generation, and the single or combined use of scientific and artistic fields has grown in acceptance. However, there are still several barriers in the large-scale adoption of serious games. How can these fields be combined to achieve the best possible results? How to increase the perceived quality of serious games in front of the latest emerging entertainment games? How to ensure the capacity of serious games as valuable learning and training tools?